CCP-EM

A multi-platform suite of computational tools covering all aspects of cryoEM data processing, from image manipulation to building atomic models.
Technology No. CCP-EM
CCP-EM Logo
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The Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) was initiated in 2012 to support the computational needs of the electron cryo-microscopy (cryoEM) community. CCP-EM is mandated to provide user training and developer support and to establish a coherent community for the exchange of best practices and novel ideas.

The CCP-EM software suite is a multi-platform suite of tools that aims to cover all aspects of cryoEM data processing from image manipulation to the building of atomic models, and to cover multiple techniques such as single-particle reconstruction and sub-tomogram averaging.

There are two versions of the software suite. Version 1 was developed between 2012 and 2022. It is still available but is no longer actively developed. CCP-EM version 2, known as Doppio, has been in development since 2022. The CCP-EM software licence covers both versions of the suite.

The software suite was conceived as a generic framework that could support a wide variety of functionalities, and has a modular organisation which can be divided into three layers. The top level is a user-friendly GUI layer. In CCP-EM version 1, this was written in Python using the PyQt toolkit. CCP-EM version 2 has a modern JavaScript GUI that can be viewed in a web browser. Distinct from this is the mid-level management layer, which is written in pure Python. This provides a bridge between the GUI layer and the third layer: the set of functional programs. These programs originate from collaborating developers and are written in a wide variety of languages (including C, C++, Fortran and Python) with distinct control methods and input conventions.


  • expand_more mode_edit Authors (11)
    Tom Burnley
    Colin Palmer
    Martyn Winn
    Matt Iadanza
    Joel Greer
    Jola Mirecka
    Sony Malhotra
    Agnel Praveen Joseph
    George Coldstream
    Rangana Warshamanage
    Rob Nicholls
  • expand_more library_books References (2)
    1. Tom Burnley, Colin M. Palmer and Martyn Winn (June 2017), Recent developments in the CCP-EM software suite, Acta Cryst., 73, 469-477
    2. Chris Wood, Tom Burnley, Ardan Patwardhan, Sjors Scheres, Maya Topf, Alan Roseman and Martyn Winn (January 2015), Collaborative Computational Project for Electron cryo-Microscopy, Acta Cryst, 71, 123-126
  • expand_more cloud_download Supporting documents (1)
    Product brochure
    CCP-EM.pdf
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CCP-EM Evaluation Licence
A 60 day evaluation licence for the CCP-EM software suite tied to the licensee's named site(s). Please note that the evaluation licence is not for commercial use and is only intended for use with published data.

Term: 60 days

Free of charge

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